The cover of April 2020 issue of Nature Materials features an image from work recently published by the Lammerding Lab. The paper entitled, “Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells” describes nuclear instability in laminopathies.
Lamin mutations responsible for muscular dystrophy are shown to reduce nuclear envelope stability, resulting in mechanically induced nuclear envelope rupture, DNA damage and activation of DNA damage response pathways that lead to muscle cell death. Preventing nuclear envelope damage by reducing cytoskeletal forces on the nucleus improves muscle fibre health and function.
The cover image, provided by Lammerding Lab Ph.D. student Tyler Kirby, presents in vitro differentiated muscle fibers containing a mutation in the gene encoding the nuclear envelope proteins lamin A/C, which causes muscular dystrophy. Nuclei (lamin B) are labeled in yellow, while the cytoskeleton (myosin heavy chain) is labeled in magenta.
More info:
A research collaboration has found an efficient way to expand the collective behavior of swarming microrobots: Mixing different sizes of the micron-scale ‘bots enables them to self-organize into... Read more about Swarming microrobots self-organize into diverse patterns
Researchers in the School of Electrical and Computer Engineering are incorporating elements of physics, circuit design, photonics, systems architecture, information theory and other fields to make... Read more about Qubit control: Cornell engineers push to make quantum practical
Mehrnaz Sabet, Mokshin Suri and Ruben Trujillo make up the latest cohort of the Cornell Engineering Commercialization Fellowship, a program that helps researchers evaluate their technology through a... Read more about Commercialization Fellows assess innovations’ potential
