
- Graduate Field Affiliations
- Biomedical and Biological Sciences
- Biomedical Engineering
- Chemical Engineering
- Stem Cell Biology (minor)
Biography
Claudia Fischbach-Teschl is the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University, Director of Cornell’s Physical Sciences Oncology Center (PSOC) on the Physics of Cancer Metabolism, and Associate Director of Cornell Nanoscale Science and Engineering Facility (CNF). She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg, Germany and conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences. Her lab utilizes engineering tools and strategies to gain a better understanding of how tumor-microenvironment interactions regulate cancer development, progression, and therapy resistance with a focus on cell-ECM interactions. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE), the Biomedical Engineering Society, and the Alexander von Humboldt Foundation in Germany.
Cellular interactions with their surrounding including other cells and extracellular matrix are critically important in the pathogenesis of cancer. However, current cancer research mostly studies cells in isolation and under conditions that do not recapitulate the mechanisms that affect tumor evolution in the human body. By exploring tissue engineering, microfabrication, and biomaterials strategies the Fischbach-Teschl lab engineers model systems that allow studying tumor cells under conditions that mimic those within patients. In particular, the Fischbach-Teschl lab uses these model systems to gain a better understanding of the biological and physical principles that influence tumor development, progression, and therapy response.
Research Interests
- Biotechnology
- Molecular and Cellular Engineering
- Polymers and Soft Matter
- Nanobio Applications
- Nanotechnology
- Mechanics of Biological Materials
- Biomedical Engineering
- Bioengineering
- Microfluidics
- Biomechanics and Mechanobiology
- Tissue Engineering and Biomaterials
- Microfluidics and Microsystems
- Multiphase and Granular Flows
Select Publications
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Seo BR, Song YH, Chen X, Ling L, Choi S, Sapudom J, Gonzalez J, Wang K, Pompe T, Gourdon D, Shenoy V, Fischbach C., Collagen microarchitecture mechanically controls myofibroblast differentiation. PNAS; 117(21):11387-11398 (2020)
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L Ling, JA Mulligan, Y Ouyang, AA Shimpi, RM Williams, BD Hopkins, SG Adie, C Fischbach, Obesity-associated Adipose Stromal Cells Promote Breast Cancer Cell Invasion Through Direct Cell Contact and ECM Remodeling. Advanced Functional Materials, (2020)
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S. Choi, Y. H. Song, J. Friedrichs, C. Werner, L. Estroff and C. Fischbach, Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration, Biomaterials; 198:95-106 (2019)
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F He, AE Chiou, HC Loh, M Lynch, BR Seo, YH Song, MJ Lee, R Hoerth, EL Bortel, B Willie, G Duda, LA Estroff, A Masic, W Wagermaier, P Fratzl, and C Fischbach, Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis. Proc Natl Acad Sci U S A; 114(40):10542-10547 (2017)
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B. R. Seo, P. Bhardwaj, S. Choi, J. Gonzalez, R. C. A. Eguiluz, K. Wang, S. Mohanan, P. G. Morris, B. Du, X. K. Zhou, L. T. Vahdat, A. Verma, O. Elemento, C. A. Hudis, R. M. Williams, D. Gourdon, A. J. Dannenberg, C. Fischbach, Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci. Transl. Med.; 7, 301ra130 (2015)
Select Awards and Honors
- Momentum Award, Biomedical Engineering Society, Cellular and Molecular Bioengineering (BMES-CMBE) 2022
- John Swanson ’61 ME Excellence in Teaching Award 2020
- Elected Fellow, Biomedical Engineering Society 2018
- Research Excellence Award, College of Engineering, Cornell University 2016
- Elected Fellow, American Institute for Medical and Biological Engineering (AIMBE) 2016
- Fellow, Alexander von Humboldt Foundation 2013
Education
- M.S., Pharmacy, Ludwig Maximilians University 1998
- Ph.D., Pharmaceutical Technology, University of Regensburg 2003