BME7900 Seminar Series - David Beebe, PhD

Description

We welcome Dr. David Beebe from the University of Wisconsin - Madison. Dr. Beebe is the Claude Bernard Professor of Biomedical Engineering.

Replicating In Vivo Micro Scale Biology In Vitro: Cancer Biology and Neutrophil Migration

Abstract: Cell biology occurs at the micro scale. I will describe two projects where we are using micro scale technology to replicate in vivo micro scale biology. In the first, we build patient-specific models of cancer with cells from that patient to replicate the tumor (and it’s microenvironment) structure and function. The model includes eight different cell types including both lymph and blood vasculature and the tumor cells in a spheroid format. We than treat these models to predict which treatment (e.g. drug, radiation) will be best for that patient. In the second, we are applying a recently developed under oil microfluidic technology to replicate the in vivo single cell scale mechanics and kinetics during neutrophil migration.

Bio: David J. Beebe is the Claude Bernard Professor of Biomedical Engineering, a University of Wisconsin John D. MacArthur Professor and a Professor of Pathology & Laboratory Medicine at the University of Wisconsin-Madison. Originally trained in Electrical Engineering, from 2004-2009 he completed a 5 year NIH funded retraining in cell/cancer biology. From 2012-2017 he co-led the Tumor Microenvironment Program in the University of Wisconsin Carbone Cancer Center. He has published >350 archived journal articles with >44,000 citations (h-index of 92). David’s current cancer related research interests center on the understanding and application of micro scale cell-based assays to understand cancer biology and response to therapy to improve cancer diagnosis and monitoring. Additional research topics include novel micro scale technology development, infectious disease biology and diagnostics. He has also co-founded several biotechnology companies.